While B7-engaged CD28 delivers a phosphoinositide 3-kinase (PI3K)-dependent co-stimulatory signal for T cell activation, CTLA-4 triggers an inhibitory signal [112,113], which hampers TCR-mediated activation of signaling molecules [114]

While B7-engaged CD28 delivers a phosphoinositide 3-kinase (PI3K)-dependent co-stimulatory signal for T cell activation, CTLA-4 triggers an inhibitory signal [112,113], which hampers TCR-mediated…

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