To conclude, IGFBP-2 stimulates GU in 3T3-L1 adipocytes through activation of PI3K/Akt, AMPK/TBC1D1, and PI3K/PKCit may exert mitogenic effects at nanomolar concentrations [3] also to induce insulin-like metabolic effects in both muscle and adipose tissues [4]

To conclude, IGFBP-2 stimulates GU in 3T3-L1 adipocytes through activation of PI3K/Akt, AMPK/TBC1D1, and PI3K/PKCit may exert mitogenic effects at nanomolar concentrations [3]…

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