Probably the ability of Rpn11 to cleave a bulk polyubiquitin chain in the proteasome top suggests that it could perform likewise at the DSB sites; it will be possible that POH1 also cleaves the ubiquitin chainsen blocoff histones or other unidentified substrates in DSB sites, which may quickly neutralize constant DSB fix signaling
Probably the ability of Rpn11 to cleave a bulk polyubiquitin chain in the proteasome top suggests that it could perform likewise at the…